Accurate Calculation of Hazardous Materials Transport Risks

Cataloged from PDF version of article.We propose two path-selection algorithms for the transport of hazardous materials. The algorithms can deal with link impedances that are path-dependent. This approach is superior to the use of a standard shortest path algorithm, common in the literature and practice, which results in inaccuracies

Designing emergency response networks for hazardous materials transportation

Cataloged from PDF version of article.Undesirable consequences of dangerous goods incidents can be mitigated by quick arrival of specialized response teams at the accident site. We present a novel methodology to determine the optimal design of a specialized team network so as to maximize its ability to respond to such incidents in a region. We show that this problem can be represented via a maximal arc-covering model.We discuss two formulations for the maximal arc-covering problem, a known one and a new one. Through computational experiments, we establish that the known formulation has excessive computational requirements for large-scale problems, whereas the alternative model constitutes a basis for an efficient heuristic. The methodology is applied to assess the emergency response capability to transport incidents, that involve gasoline, in Quebec and Ontario. We point out the possibility of a significant improvement via relocation of the existing specialized teams, which are currently stationed at the shipment origins. 2005 Elsevier Ltd. All rights reserved

Matching patient and physician preferences in designing a primary care facility network

Cataloged from PDF version of article.This paper introduces an integer programming model for planning primary care facility networks, which accounts for the interests of different stakeholders while maximizing access to health care. Physician allocation to health-care facilities is explicitly modelled, which allows consideration of physician incentives in the planning phase. An illustrative case study in the Turkish primary care system is presented to show the implications of focusing on patient or physician preferences in the planning phase. A discussion of trade-offs between the different stakeholder preferences and some recommendations for modelling choices to match these preferences are provided. In the context of this case, we found that using an access measure that decays with distance, and incorporating nearest allocation constraints improves performance for all stakeholders. We also show that increasing the number of physicians may have adverse affects on access measures when physician preferences are addressed

Designing Personalized Treatment: An Application to Anticoagulation Therapy

In this study, we develop an analytical framework for personalizing the anticoagulation therapy of patients who are taking warfarin. Consistent with medical practice, our treatment design consists of two stages: (i) the initiation stage, modeled using a partially-observable Markov decision process, during which the physician learns through systematic belief updates about the unobservable patient sensitivity to warfarin, and (ii) the maintenance stage, modeled using a Markov decision process, during which the physician relies on his formed belief about patient sensitivity to determine the stable, patient-specific, warfarin dose to prescribe. We develop an expression for belief updates in the POMDP, establish the optimality of the myopic policy for the MDP, and derive conditions for the existence and uniqueness of a myopically optimal dose. We validate our models using a real-life patient data set gathered at the Hematology Clinic of the Jewish General Hospital in Montreal. The proposed analytical framework and case study enable us to develop useful clinical insights, for example, concerning the length of the initiation period and the importance of correctly assessing patient sensitivity

Designing a road network for hazardous materials transportation

Dangerous-goods shipments remain regulated despite the widespread deregulation of the transportation industry. This is mainly due to the societal and environmental risks associated with these shipments. One of the common tools used by governments in mitigating transport risk is to close certain roads to vehicles carrying hazardous materials. In effect, the road network available to dangerous goods carriers can be determined by the government. The associated transport risk, however, is determined by the carriers' route choices. We provide a bilevel programming formulation for this network design problem. Our approach is unique in terms of its focus on the nature of the relationship between the regulator and carriers. We present an application of our methodology in Western Ontario, Canada. © 2004 INFORMS

An integrated evaluation of facility location, capacity acquisition, and technology selection for designing global manufacturing strategies

Emergence of global markets enhanced the emergence of global firms which have plants in different countries and implement an integrated management style. Due to the intensive competition in global markets, manufacturing performance is conceived as an important strategic weapon. Facility location, capacity acquisition and technology selection decisions constitute means to implement manufacturing strategies. We review the literature in order to contribute to a better understanding of global manufacturing strategies. As a result we observe that an integrated analysis of the location, capacity and technology decisions is vital for the design of effective global manufacturing strategies. © 1992

Chapter 9 Hazardous Materials Transportation

[No abstract available

The Incremental Cooperative Design of Preventive Healthcare Networks

This document is the Accepted Manuscript version of the following article: Soheil Davari, 'The incremental cooperative design of preventive healthcare networks', Annals of Operations Research, first published online 27 June 2017. Under embargo. Embargo end date: 27 June 2018. The final publication is available at Springer via http://dx.doi.org/10.1007/s10479-017-2569-1.In the Preventive Healthcare Network Design Problem (PHNDP), one seeks to locate facilities in a way that the uptake of services is maximised given certain constraints such as congestion considerations. We introduce the incremental and cooperative version of the problem, IC-PHNDP for short, in which facilities are added incrementally to the network (one at a time), contributing to the service levels. We first develop a general non-linear model of this problem and then present a method to make it linear. As the problem is of a combinatorial nature, an efficient Variable Neighbourhood Search (VNS) algorithm is proposed to solve it. In order to gain insight into the problem, the computational studies were performed with randomly generated instances of different settings. Results clearly show that VNS performs well in solving IC-PHNDP with errors not more than 1.54%.Peer reviewe

A biologically inspired network design model

A network design problem is to select a subset of links in a transport network that satisfy passengers or cargo transportation demands while minimizing the overall costs of the transportation. We propose a mathematical model of the foraging behaviour of slime mould P. polycephalum to solve the network design problem and construct optimal transport networks. In our algorithm, a traffic flow between any two cities is estimated using a gravity model. The flow is imitated by the model of the slime mould. The algorithm model converges to a steady state, which represents a solution of the problem. We validate our approach on examples of major transport networks in Mexico and China. By comparing networks developed in our approach with the man-made highways, networks developed by the slime mould, and a cellular automata model inspired by slime mould, we demonstrate the flexibility and efficiency of our approach